Dose-dependent effects of traxoprodil and fluoxetine in mice

The traxoprodil (Sigma-Aldrich, St. Louis, USA) doses were dissolved in 0.9% saline containing 1% Tween-80, and the fluoxetine hydrochloride (Sigma-Aldrich, St. Louis, USA) doses were dissolved in 0.9% saline. Mice were administered traxoprodil (10 mg/kg, 20 mg/kg, and 40 mg/kg, i.p.), fluoxetine hydrochloride (5 mg/kg, i.p.), or 0.9% saline for 7, 14, and 21 days, respectively. All drug solutions used in this study were administered at a volume of 10 ml/kg and prepared just before use.

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Wang Y., Liang Z., Song W., Qin Y., Todd N, & Gao M. (2023). Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2023, 1131422.

Publication 2023

traxoprodil fluoxetine hydrochloride

0 9 saline Drug solutions Fluoxetine hydrochloride Mice Traxoprodil Tween

Corresponding Organization : China Medical University

Other organizations : Indiana University Fort Wayne

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Variable analysis

independent variables

Traxoprodil doses (10 mg/kg, 20 mg/kg, and 40 mg/kg, i.p.)
Fluoxetine hydrochloride dose (5 mg/kg, i.p.)
Saline (0.9%)

dependent variables

Not explicitly mentioned

control variables

Tween-80 (1%) was used to dissolve traxoprodil doses
All drug solutions were administered at a volume of 10 ml/kg
All drug solutions were prepared just before use

controls

Positive control: Fluoxetine hydrochloride (5 mg/kg, i.p.)
Negative control: 0.9% saline

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