Synthesis and Characterization of Psychoactive Compounds

Bupropion hydrochloride and 6-hydroxybupropion were obtained from Toronto Research Chemicals (Toronto, Canada), ibogaine from Ibogaworld, cocaine from Medisca (Montreal, Canada), β-PEA, pinoline, indole, tryptamine, ephedrine, frovatriptan, alprenolol, isoproterenol, evodiamine, and tyramine from Sigma (Oakville, Canada), fluoxetine and amphetamine were from Tocris Bioscience (Bristol, United Kingdom). PAL analogs, RTI analogs, and bicifadine were synthesized at RTI in the Blough laboratory as described previously (Carroll et al., 2009 (link), 2011 (link); Blough et al., 2011 , 2014 (link)). Noribogaine (Batch No. 606950002) was from Deborah Mash, Ph.D. (Obach et al., 1998 ). Ibogamine was obtained from Specs (Zoetermeer, The Netherlands). Sodium phenylbutyrate was purchased from Enzo Life Sciences Inc. (Farmingdale, NY). Ibogaminalog, ibogainealog, noribogainalog, fluorogainalog, and tabernanthalog were synthesized in the lab of David E. Olson (Cameron et al., 2020 (link)).

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Sutton C., Williams E.Q., Homsi H., Beerepoot P., Nazari R., Han D., Ramsey A.J., Mash D.C., Olson D.E., Blough B, & Salahpour A. (2022). Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones. Frontiers in Cellular Neuroscience, 16, 832536.

Publication 2022

Bupropion hydrochloride β-PEA indole tryptamine ephedrine alprenolol isoproterenol evodiamine tyramine fluoxetine amphetamine

Alprenolol Amphetamine Bicifadine Bupropion hydrochloride Cocaine Ephedrine Evodiamine Fluoxetine Frovatriptan Hydroxybupropion Ibogaine Ibogamine Indole Isoproterenol Noribogaine Pinoline Sodium phenylbutyrate Tryptamine Tyramine

Corresponding Organization : University of Toronto

Other organizations : University of Miami, University of California, Davis, RTI International

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Variable analysis

independent variables

Bupropion hydrochloride
6-hydroxybupropion
Ibogaine
Cocaine
β-PEA
Pinoline
Indole
Tryptamine
Ephedrine
Frovatriptan
Alprenolol
Isoproterenol
Evodiamine
Tyramine
Fluoxetine
Amphetamine
PAL analogs
RTI analogs
Bicifadine
Noribogaine
Ibogamine
Sodium phenylbutyrate
Ibogaminalog
Ibogainealog
Noribogainalog
Fluorogainalog
Tabernanthalog

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

Positive controls: None specified
Negative controls: None specified

Annotations

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