Allele Frequency Analysis of Cardiovascular Traits
MAFs were assessed across the IBCv1 arrays in 6067 DNA samples collated from three studies with five populations of self described ethnicity, screened for cardiovascular traits; Caucasians (n = 4244 European and n = 1054 US Caucasians); African Americans (n = 384) and South Asians (n = 385). All samples described were genotyped following approval by the relevant institutional review boards. In each respective population, the minor allele frequency for each SNP on the IBCv1 array was determined. Histograms were generated with various allele frequency bins to determine the distribution of allele frequencies in each population.
Keating B.J., Tischfield S., Murray S.S., Bhangale T., Price T.S., Glessner J.T., Galver L., Barrett J.C., Grant S.F., Farlow D.N., Chandrupatla H.R., Hansen M., Ajmal S., Papanicolaou G.J., Guo Y., Li M., DerOhannessian S., de Bakker P.I., Bailey S.D., Montpetit A., Edmondson A.C., Taylor K., Gai X., Wang S.S., Fornage M., Shaikh T., Groop L., Boehnke M., Hall A.S., Hattersley A.T., Frackelton E., Patterson N., Chiang C.W., Kim C.E., Fabsitz R.R., Ouwehand W., Price A.L., Munroe P., Caulfield M., Drake T., Boerwinkle E., Reich D., Whitehead A.S., Cappola T.P., Samani N.J., Lusis A.J., Schadt E., Wilson J.G., Koenig W., McCarthy M.I., Kathiresan S., Gabriel S.B., Hakonarson H., Anand S.S., Reilly M., Engert J.C., Nickerson D.A., Rader D.J., Hirschhorn J.N, & FitzGerald G.A. (2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. PLoS ONE, 3(10), e3583.
Publication 2008
African americans Cardiovascular CaucasiansEthnicity European Institutional review boards Mafs South asians
Corresponding Organization : University of Pennsylvania
Other organizations :
Broad Institute, Massachusetts Institute of Technology, Boston Children's Hospital, Scripps Institution of Oceanography, Scripps (United States), University of Washington, Psychiatry Research Trust, Children's Hospital of Philadelphia, Illumina (United States), Wellcome Centre for Human Genetics, University of Oxford, Cardiovascular Institute of the South, National Heart Lung and Blood Institute, BGI Group (China), Brigham and Women's Hospital, Harvard University, McGill University, McGill University and Génome Québec Innovation Centre, Cedars-Sinai Medical Center, University of California, Los Angeles, The University of Texas Health Science Center at Houston, Lund University, Helsinki University Hospital, University of Michigan–Ann Arbor, Michigan United, University of Leeds, Peninsula College of Medicine and Dentistry, University of Cambridge, NHS Blood and Transplant, William Harvey Research Institute, University of Leicester, Rosetta Stone (United States), University of Mississippi Medical Center, Universität Ulm, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Massachusetts General Hospital, Hamilton General Hospital, Hamilton Health Sciences, McMaster University
Ethnicity (Caucasians, African Americans, South Asians)
dependent variables
Minor allele frequency for each SNP on the IBCv1 array
control variables
Cardiovascular traits
Samples were genotyped following approval by the relevant institutional review boards
controls
Positive control: Not specified
Negative control: Not specified
Annotations
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