All data processing, except the QSM (which was obtained by the free tool described in [34 (link)]), was performed using an in-house developed library for Matlab (MATLAB® Release 2012b, The MathWorks, Inc., Natick, MA, USA), partly described in previous works [16 (link), 35 –37 (link)], on a commercial workstation (Intel® Core i7-3820 CPU @ 3.6 GHz; RAM 16 GB) equipped with 2 GPU boards (NVIDIA GeForce® GTX 690). The demonstrative application of qMRI for vein segmentation, and Oxygen Extraction Fraction (OEF) and MTVF mapping was respectively provided by the MAVEN algorithm [20 ] and the in-house implementations of the methods described in [27 (link), 38 (link)].
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