Lung CT Imaging Protocol for ILA Diagnosis

Full lung MESA CT scans were acquired in years 2010-12 at suspended full inspiration on 64-slice scanners (GE and Siemens) using the MESA Lung/SPIROMICS protocol (See supplementary appendix) [28 ]. Images were reconstructed using 0.625 mm slice thickness, as previously described [29 (link)]. ILA was defined as the presence of ground-glass, reticular abnormality, diffuse centrilobular nodularity, honeycombing, traction bronchiectasis, non-emphysematous cysts or architectural distortion in at least 5% of nondependent portions of the lung, using methodology previously described [6 (link), 8 (link), 30 (link)].

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Podolanczuk A.J., Oelsner E.C., Barr R.G., Hoffman E.A., Armstrong H.F., Austin J.H., Basner R.C., Bartels M.N., Christie J.D., Enright P.L., Gochuico B.R., Stukovsky K.H., Kaufman J.D., Nath P.H., Newell JD J.r., Palmer S.M., Rabinowitz D., Raghu G., Sell J.L., Sieren J., Sonavane S.K., Tracy R.P., Watts J.R., Williams K., Kawut S.M, & Lederer D.J. (2016). High Attenuation Areas on Chest CT in Community-Dwelling Adults: The MESA Study. The European respiratory journal, 48(5), 1442-1452.

Publication 2016

64-slice scanners

Bronchiectasis Ct scans Cysts Emphysematous Inspiration Lung Reticular abnormality Traction

Corresponding Organization :

Other organizations : Columbia University Irving Medical Center, Zero to Three, University of Iowa, Montefiore Medical Center, Albert Einstein College of Medicine, University of Pennsylvania, University of Arizona, National Human Genome Research Institute, University of Washington, University of South Alabama, University of Alabama, Clinical Research Institute, Duke University, Columbia University, Vida Diagnostics (United States), University of Vermont

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Variable analysis

independent variables

Full lung MESA CT scans acquired in years 2010-12 at suspended full inspiration on 64-slice scanners (GE and Siemens) using the MESA Lung/SPIROMICS protocol

dependent variables

Presence of ground-glass, reticular abnormality, diffuse centrilobular nodularity, honeycombing, traction bronchiectasis, non-emphysematous cysts or architectural distortion in at least 5% of nondependent portions of the lung

control variables

Images reconstructed using 0.625 mm slice thickness, as previously described

controls

No positive or negative controls were explicitly mentioned.

Annotations

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