Macrolide Antibiotics and Cardiac Outcomes

This meta-analysis was registered in PROSPERO (CRD42021260724). We followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines for this meta-analysis. Two independent investigators (Yang Wu and Wen-Tao Bi) performed the literature search using Medline, EMBASE databases and ClinicalTrials.gov. The computer-based searches included the keywords “macrolides,” “azithromycin,” “erythromycin,” “clarithromycin,” “roxithromycin,” “cardiac,” “heart,” “cardiovascular,” “death,” “stroke,” “myocardial infarction,” “acute coronary syndrome,” “ventricular tachycardia,” “arrhythmia,” “sudden cardiac death,” “cardiac arrest,” “torsades de pointes,” “sudden death,” and “mortality.”