Quantifying SARS-CoV-2 Antibodies Post-Infection

313 serum samples from 155 individuals with previous SARS-CoV-2 infection (with or without SARS-CoV-2 vaccination) were analyzed by two commercially available assays according to the instructions of the manufacturer (anti-SARS-CoV-2-QuantiVac-ELISA (IgG), Euroimmun, Lübeck, Germany and Elecsys Anti-SARS-CoV-2 S, Roche, Mannheim, Germany). For individuals who have been measured several times, the sera were obtained from independent plasma donations performed at different dates. Samples were collected after written informed consent was obtained from convalescent plasma donors (22 (link)) and vaccinated individuals. The studies were approved by the Ethical Committee of University of Ulm and Ethical Committee II, Heidelberg University (392/20, 488/20, 56/21 and 41/22).

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Seidel A., Hoffmann S., Jahrsdörfer B., Körper S., Ludwig C., Vieweg C., Albers D., von Maltitz P., Müller R., Lotfi R., Wuchter P., Klüter H., Kirchhoff F., Schmidt M., Münch J, & Schrezenmeier H. (2023). SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays. Frontiers in Immunology, 14, 1170759.

Publication 2023

anti-SARS-CoV-2-QuantiVac-ELISA (IgG), Anti-SARS-CoV-2 S

Assays Donors Elisa Plasma Plasma donations Sars cov 2 Sars cov 2 infection Sera Vaccination

Corresponding Organization : University Hospital Ulm

Other organizations : Heidelberg University, Heidelberg University, University Hospital Heidelberg

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Variable analysis

independent variables

SARS-CoV-2 infection status (with or without SARS-CoV-2 vaccination)

dependent variables

Anti-SARS-CoV-2 antibody levels measured by two commercially available assays (anti-SARS-CoV-2-QuantiVac-ELISA (IgG) and Elecsys Anti-SARS-CoV-2 S)

control variables

Time of plasma donation (independent plasma donations performed at different dates)

positive controls

Sera from convalescent plasma donors with previous SARS-CoV-2 infection
Sera from vaccinated individuals

negative controls

Not explicitly mentioned

Annotations

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