The ABO Study recruited healthy volunteers (non-pregnant/lactating women and men, age 18–50) to a single study visit at the University of Pennsylvania from 2012 to 2014, as described53 (link). Plasma metabolomics profiling, including measurement of kynurenine, was carried out at Metabolon (Metabolon Inc, Morrisville, NC; global metabolomics platform). Genotyping was performed using the Exome chip (Illumina, CoreExome, N > 540,000 variants, including rs3184504) at the Center for Applied Genomics at the Children's Hospital of Philadelphia. We analyzed data for a subset of individuals with overlapping metabolite and genetic data (N = 66).
The GENE and ABO studies were approved by the IRB of the University of Pennsylvania and Vanderbilt University. All participants provided written informed consent.
The GENE and ABO studies were approved by the IRB of the University of Pennsylvania and Vanderbilt University. All participants provided written informed consent.
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