Quantification of 12 PFAS in Serum Samples
Corresponding Organization : University of Illinois Urbana-Champaign
Other organizations : California Environmental Protection Agency, University of California, Berkeley
Protocol cited in 6 other protocols
Variable analysis
- None explicitly mentioned
- Concentrations of 12 PFAS compounds: perfluoro butane sulfonate (PFBS), perfluorohexanesulphonic acid (PFHxS), perflucorooctane sulfonic acid (PFOS), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), perfluorooctane sulfonamide (PFOSA), methyl-perfluorooctane sulfonamide acetic acid (Me-PFOSA-AcOH), ethyl-perfluorooctane sulfonamide acetic acid (Et-PFOSA-AcOH)
- Serum samples from both cohorts are centrifuged and aliquoted prior to storage at −80 °C at cohort sites and later stored at −20 °C at the Environmental Chemical Laboratory at the California Department of Toxic Substances Control (DTSC)
- The samples are extracted and analyzed using a Symbiosis Pharma automated online solid-phase extraction system (Spark Holland) coupled with liquid chromatography and tandem mass spectrometry to quantify PFAS
- The method detection limit (MDL) is calculated as 3 times the standard deviation of the blank concentrations for all PFAS
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