This part of the method has been described in detail in previous studies (14 (link)). Briefly, participants underwent head CTA. All participants were injected with 60 mL of contrast agent (iodide 370 mg/mL, Bayer, Germany), followed by 40 mL of normal saline collection agent at an injection rate of 4 mL/s. The scan was performed with a 64-section cardiac CT scanner (CT750 HD, GE, USA) using a standardized optimized contrast-enhanced protocol (120 kV [peak]; 180 mAs; collimation, 64 × 0.625 mm; rotation time, 0.5 s; pitch, 1.375). The head CT scan range was from the carotid bifurcation to the parietal region. An aneurysm was defined as an abnormal swelling or bulge of an intracranial artery (16 (link)). Aneurysms were jointly diagnosed by a senior radiologist and senior neurosurgeon. None of the patients included in this study had a high suspicion intracranial aneurysm.
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