Mouse Models and Pharmacological Treatments

Male Fos^2A-iCreER mice (TRAP2) (Jax 030323) and adult male and female C57/BL6 mice (16–24 weeks old) were purchased from The Jackson Laboratory. Mice were housed in a temperature-controlled vivarium on a 12-hour light/12-hour dark cycle (lights on at 0700 hours; lights off at 1900 hours) with ad libitum access to food and water. CD1 male mice (16–26 weeks old,) and male SD rats (10–14 weeks old) were also purchased from The Jackson Laboratory and Charles River Laboratories, respectively. For carbamazepine, oral gavage of carbamazepine (Novartis, packaged by Precision Dose) at 60 mg/kg was used. For ketorolac (Hospira), oral gavage of 10 mg/kg was used. For tamoxifen (MilliporeSigma, WXBD4583V), intraperitoneal injection of 150 mg/kg dissolved in corn oil was used.