Participants were recruited from the East Flanders Prospective Twin Survey (EFPTS; [15 (link)]), a prospective population-based, multi-birth registry situated in Flanders, Belgium. Zygosity was determined through sequential analysis based on sex, fetal membranes, umbilical cord blood groups, placental alkaline phosphatase, and DNA fingerprints (EFPTS; [15 (link)]). Individuals who were registered in the EFPTS and who fulfilled the inclusion criteria were invited to participate in the TwinssCan project, a longitudinal study collecting data on adolescents and young adults between the ages of 15 and 35 years, including twins, their siblings, and parents. The TwinssCan project, which started enrollment in April 2010, is a general population based, ongoing longitudinal study [16 ] and currently contains information on 1116 participants; twins (n = 830), siblings (n = 43), and parents (n = 234). Participants were included if they clearly understood the study procedure and were able to provide valid, reliable, and complete data. All participants gave written informed consent; for participants below the age of 18, parent(s) also signed an informed consent. Participants were excluded if they had a pervasive mental disorder as indicated by caregivers. The local ethics committee (Commissie Medische Ethiek van de Universitaire ziekenhuizen KU Leuven, Nr. B32220107766) approved the study. The current study used a subpopulation of the TwinssCan (n = 704) including only monozygotic (MZ) and dizygotic (DZ) twin pairs with complete data on SIS-R, the white noise task, age and sex. Table 1 reports the overview of the demographic variables.
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