Synthesis of PEGylated Gold Nanoparticles

PEGylated Au NPs were prepared by sputtering of gold into liquid medium. A starting material for synthesis of Au NPs was Au target (of 99.99 % purity, Safina, a. s., CZ). As for liquid media, which served as stabilizing agents as well, we used two types of polyethylene glycols (both supplied by Sigma-Aldrich Corp., US): (i) polyethylene glycol (PEG, M_w = 400 g/mol) and (ii) polyethylene glycol methyl ether amine (PEG-NH₂, M_w = 500 g/mol). Amine terminated polyethylene glycol was mixed with pure PEG in weight ratio 20:1 (PEG:PEG-NH₂).

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Nguyenova H.Y., Hubalek Kalbacova M., Dendisova M., Sikorova M., Jarolimkova J., Kolska Z., Ulrychova L., Weber J, & Reznickova A. (2024). Stability and biological response of PEGylated gold nanoparticles. Heliyon, 10(9), e30601.

Publication 2024

Corresponding Organization :

Other organizations : University of Chemistry and Technology, Technical University of Liberec, Charles University, Jan Evangelista Purkyně University in Ústí nad Labem, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

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Variable analysis

independent variables

Sputtering of gold into liquid medium

dependent variables

Characteristics of the PEGylated Au NPs

control variables

Gold target (of 99.99% purity, Safina, a. s., CZ)
Polyethylene glycol (PEG, Mw = 400 g/mol)
Polyethylene glycol methyl ether amine (PEG-NH2, Mw = 500 g/mol)
Amine terminated polyethylene glycol was mixed with pure PEG in weight ratio 20:1 (PEG:PEG-NH2)

controls

Positive control: Not mentioned
Negative control: Not mentioned

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