Depressive episodes secondary to a systemic disease or neurological disorder, such as depression due to hypothyroidism.
Received modified electric convulsive therapy (MECT), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS) or vagus nerve stimulation (VNS) within 3 months before screening.
Withdrawal of psychotropic drugs did not equate to seven half-life periods before the screening.
Women with a positive blood human chorionic gonadotropin (HCG)/urine HCG test; men with reproductive potential and women of reproductive age unable to use contraception effectively and women who plan to become pregnant within 3 months of the start of the study.
Participated in any interventional clinical trial 3 months before screening.