Intravenous Prostate Tumor Visualization

Example 2

20 mg of a compound of formula III in 10 ml of sterile water can be administered intravenously to patients. Laparoscopic ports can then be placed and the da Vinci Surgical System connected to the ports. The endoscope of the system can then be directed at the prostate of the patient, and laser excitation at approximately 800 nm can be used to excite the composition of formula III within the prostate. A small amount of blue and green light can also be emitted in order to allow visualization of the background anatomy. Approximately 2-24 hours after administration, visualization of the prostate and prostate tumor tissue can be achieved as the composition of formula III has bound to PSMA.

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US11857645B2. Compositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands (2024-01-02). Intuitive Surgical Operations, Inc. [US]. Inventors: Jonathan M. Sorger [US].

Patent 2024

Compound 20 Endoscope Laparoscopic Light Patient Prostate Prostate tumor Sterile Surgical Tissue

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Variable analysis

independent variables

Administration of 20 mg of a compound of formula III in 10 ml of sterile water intravenously to patients

dependent variables

Visualization of the prostate and prostate tumor tissue
Binding of the composition of formula III to PSMA

control variables

Placement of laparoscopic ports
Connection of the da Vinci Surgical System to the ports
Direction of the endoscope of the system at the prostate of the patient
Laser excitation at approximately 800 nm to excite the composition of formula III within the prostate
Emission of a small amount of blue and green light to allow visualization of the background anatomy
Time of approximately 2-24 hours after administration for visualization of the prostate and prostate tumor tissue

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