Ketamine Dosage and Administration for Behavioural Studies

Ketamine hydrochloride (Ketaset, Henry Schein Animal Health, UK) was diluted in a normal saline vehicle to 25 mg/mL or 8 mg/mL and administered intraperitoneally (IP) at 1 mL/kg 30 min prior or immediately following conditioning training or recall trials. The resulting subanaesthetic doses of 25 mg/kg or 8 mg/kg are consistent with previous studies (Bolton et al., 2012 (link); Razoux et al., 2007 (link)).

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Clifton N.E., Thomas K.L, & Hall J. (2018). The effect of ketamine on the consolidation and extinction of contextual fear memory. Journal of Psychopharmacology (Oxford, England), 32(2), 156-162.

Publication 2018

Ketaset

Animal Ketamine hydrochloride Ketaset Normal saline Recall

Corresponding Organization : Cardiff University

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Variable analysis

independent variables

Ketamine hydrochloride (Ketaset, Henry Schein Animal Health, UK) dilution concentration (25 mg/mL or 8 mg/mL)
Timing of ketamine administration (30 min prior or immediately following conditioning training or recall trials)

dependent variables

Not explicitly mentioned

control variables

Normal saline vehicle
Ketamine dosage (25 mg/kg or 8 mg/kg)

controls

Positive control: Previous studies using similar subanaesthetic doses of ketamine (25 mg/kg or 8 mg/kg) (Bolton et al., 2012; Razoux et al., 2007)

Annotations

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