To examine associations between right posterior cerebellum-motor system connectivity on measures of ASD symptom severity and visual-motor skills, we constructed multiple linear regression models with connectivity, diagnosis by connectivity interaction terms, and subject-specific confounder variables (age, sex, mean FD, MRI coil, GAI) as predictors of social-communicative symptoms (total raw SRS or SRS-2), repetitive behaviors (total RBS-R), motor imitation, and ball catching, separately. We also ran each model with nonsignificant interaction terms removed to investigate the effect of right posterior cerebellum-motor functional connectivity on social deficit and repetitive behavior severity across all children (Nebel et al., 2016 (link)). FDR was used to correct for multiple comparisons (α=0.05, n tests = 56). Regression analyses were performed using IBM SPSS Statistics Package 25.0 (IBM, Armonk, NY).
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Cerebellar Connectivity and ASD Symptoms
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Corresponding Organization : Johns Hopkins University
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Variable analysis
independent variables
- Right posterior cerebellum-motor system connectivity
- Diagnosis by connectivity interaction terms
- Social-communicative symptoms (total raw SRS or SRS-2)
- Repetitive behaviors (total RBS-R)
- Motor imitation
- Ball catching
- Mean FD
- MRI coil
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