The treatment was carried out orally by gavage. In the control and SHAM groups, no treatment was performed, and in the PG, the administration of the formulation containing pterostilbene as the active ingredient was performed. One dose of the drug was administered two hours before the induction of arthritis to all groups; groups 0 were euthanized 12 hours after induction; groups 3 received daily treatment (every 24h) with doses of 0.5 mL at the given concentrations (4 mg/kg; 200 mg/kg; 400 mg/kg), they were euthanized 72h after induction.
Protocol detail
Pterostilbene Attenuates Arthritis Progression
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Corresponding Organization :
Other organizations : Universidade Estadual do Centro-Oeste, Universidade do Estado do Pará
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Variable analysis
independent variables
- Dose of the drug containing pterostilbene as the active ingredient (4 mg/kg, 200 mg/kg, 400 mg/kg)
- Arthritis induction
- Time of euthanasia (12 hours or 72 hours after induction)
- Route of administration (oral by gavage)
- Timing of drug administration (one dose two hours before induction)
- Control group: No treatment performed
- SHAM group: No treatment performed
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