The release of ketorolac from sol-gel silica preparations was performed
in balanced salt solution with a dialysis bag over time. Briefly, 2 mg of
SG-Ket-LBL particles were weighed and transferred into a dialysis bag
(Fisherbrand Regenerated Cellulose Dialysis Tubing, MWCO 12,000–14,000
D). The dialysis bag was then soaked in 4.5 mL of a balanced salt solution and
incubated at 37°C on a shaker. Every day the dialysis bag was transferred
to a new tube with the same amount of fresh balanced salt solution, and the old
aliquot was stored at −80°C until quantitation. The drug
concentrations of ketorolac in the dissolution samples were quantified by
high-performance liquid chromatography (HPLC) with tandem mass spectrometry
(MS/MS)12 (link).
in balanced salt solution with a dialysis bag over time. Briefly, 2 mg of
SG-Ket-LBL particles were weighed and transferred into a dialysis bag
(Fisherbrand Regenerated Cellulose Dialysis Tubing, MWCO 12,000–14,000
D). The dialysis bag was then soaked in 4.5 mL of a balanced salt solution and
incubated at 37°C on a shaker. Every day the dialysis bag was transferred
to a new tube with the same amount of fresh balanced salt solution, and the old
aliquot was stored at −80°C until quantitation. The drug
concentrations of ketorolac in the dissolution samples were quantified by
high-performance liquid chromatography (HPLC) with tandem mass spectrometry
(MS/MS)12 (link).
