Longitudinal Brain Imaging of PLWH

All imaging was conducted on either a Siemens TIM Trio 3-Tesla MRI
scanner with a 12-channel head coil or Siemens Prisma fit 3-Tesla scanner with a
64-channel head coil. In order to mitigate measurement error across head coils,
participants who switched scanner from baseline to follow-up were not included
in the study. We acquired 3D-T1-weighted Magnetization Prepared Rapid Gradient
Echo (MP-RAGE) sequences (240×256 matrix; FOV =256 mm; 160 slices; voxel
size =1.0 ×1.0 ×1.0mm³; TR =2300 ms; TE =2.98 ms; flip
angle =9°). Quality assurance was performed by visually inspection.
Images with excessive motion or image artifact and subsequently excluded.
Acquisition parameters were near identical on the Siemens Prisma Fit scanner,
but acquired with a 64-channel head coil. Cross-sectional volume extraction and
longitudinal analyses consisted of using a framework previously
described.^{21 (link)} A single
group template was created using a mix of PLWH and uninfected controls for final
target registration.

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Samboju V., Cobigo Y., Paul R., Naasan G., Hillis M., Tsuei T., Javandel S., Valcour V, & Milanini B. (2021). Cerebrovascular disease correlates to longitudinal brain atrophy in virally suppressed older people living with HIV. Journal of acquired immune deficiency syndromes (1999), 87(4), 1079-1085.

Publication 2021

TIM Trio 3-Tesla MRIscanner Prisma Fit scanner

Head Head measurement Prisma Rage Tim 3 Trio

Corresponding Organization : University of California, San Francisco

Other organizations : University of Missouri–St. Louis, Missouri Institute of Mental Health, Icahn School of Medicine at Mount Sinai, Global Brain Health Institute

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Variable analysis

independent variables

Scanner type (Siemens TIM Trio 3-Tesla MRI scanner with a 12-channel head coil or Siemens Prisma fit 3-Tesla scanner with a 64-channel head coil)

dependent variables

Brain volume measures extracted from T1-weighted MRI images

control variables

Participants who switched scanner from baseline to follow-up were not included in the study to mitigate measurement error across head coils
Acquisition parameters were kept near identical on the Siemens Prisma Fit scanner, but acquired with a 64-channel head coil
A single group template was created using a mix of PLWH and uninfected controls for final target registration

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