PET Neuroimaging with MRI-Integrated Scanner

The PET data were acquired on a prototype MR-compatible brain PET scanner (“BrainPET”) designed to fit inside the Magnetom Tim Trio 3T MRI scanner (Siemens Healthcare, Erlangen, Germany). Structural T1 images were acquired prior to radiotracer injection. Dynamic PET acquisition started concurrently with an injected IV bolus of ¹¹C-PBR28, and data were stored in listmode format. T1 images were used for the generation of attenuation correction maps^{19 (link)} as well as anatomical localization and spatial normalization of the PET data.

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Hadjikhani N., Albrecht D.S., Mainero C., Ichijo E., Ward N., Granziera C., Zürcher N.R., Akeju O., Bonnier G., Price J., Hooker J.M., Napadow V., Nahrendorf M., Loggia M.L, & Moskowitz M.A. (2020). Extra-axial inflammatory signal in parameninges in migraine with visual aura. Annals of neurology, 87(6), 939-949.

Publication 2020

BrainPET Magnetom Tim Trio 3T MRI scanner

11c pbr28 Brain Trio

Corresponding Organization : Harvard University

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Variable analysis

independent variables

Injection of ^11C-PBR28 radiotracer

dependent variables

PET data acquisition
Structural T1 image acquisition

control variables

Magnetom Tim Trio 3T MRI scanner (Siemens Healthcare, Erlangen, Germany)
T1 images used for attenuation correction maps and anatomical localization/spatial normalization of PET data

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