Multiplex ELISA-based Biomarker Profiling

Serum levels (pg/mL) of 35 blood-based markers were assessed in blood samples from the SELCoH cohort using multiplex ELISA-based technology provided by the Meso Scale Discovery Biomarker kits, as described previously^{48 (link)}. For each marker, we adjusted for the effects of assay run, age, gender, body mass index (BMI), smoking (never, current, former) and ethnicity, by taking standardized residuals (z-scores). Z-scores were then used in downstream PRS analyses.

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Powell T.R., Duarte R.R., Hotopf M., Hatch S.L., de Mulder Rougvie M., Breen G.D., Lewis C.M, & Nixon D.F. (2020). The behavioral, cellular and immune mediators of HIV-1 acquisition: New insights from population genetics. Scientific Reports, 10, 3304.

Publication 2020

Biomarker kits

Assay Biomarker Blood Body mass index Elisa Ethnicity Serum

Corresponding Organization : King's College London

Other organizations : Cornell University

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Variable analysis

independent variables

Assay run
Gender
Body mass index (BMI)
Smoking (never, current, former)
Ethnicity

dependent variables

Serum levels (pg/mL) of 35 blood-based markers

control variables

Assay run
Gender
Body mass index (BMI)
Smoking (never, current, former)
Ethnicity

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