Malaria Prevention in Côte d'Ivoire

While the standard-of-care for clinical management of malaria and vector control interventions (e.g., LLINs, IRS) will not be withheld in either the study arm, these interventions will be monitored and recorded throughout the trial. At baseline, children enrolled into the cohorts will be provided a 3-day course of standard, first-line antimalarials (Coartem® or ASAQ Winthrop®, both Artemisinin combination therapies (ACTs) recommended by the NMCP in Côte d’Ivoire) to clear any malaria parasite infections as well as a new LLIN. In addition, subjects will be provided treatment for malaria infection throughout the follow-up period. Lastly, participants will be encouraged to continue LLIN use and not instructed to avoid alternative vector control tools (e.g., coils, topicals, aerosol sprays, repellents) which will allow for an estimation of the ET effect assuming all other measures are still occurring for malaria prevention, essentially providing insight on an additive benefit above that provided by currently recommended WHO malaria preventive measures.

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N’Guessan R., Assi S.B., Koffi A., Ahoua Alou P.L., Mian A., Achee N.L., Fustec B., Grieco J.P., Liu F., Kumar S., Noffsinger M., Hudson A., Möhlmann T.W, & Farenhorst M. (2023). EaveTubes for control of vector-borne diseases in Côte d’Ivoire: study protocol for a cluster randomized controlled trial. Trials, 24, 704.

Publication 2023

Aerosol sprays Antimalarials Artemisinin Children Coartem Combination therapies Infection Malaria Nmcp Parasite infections

Corresponding Organization :

Other organizations : University of Notre Dame

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Estimation of the ET (Entomological) effect

control variables

Provision of standard-of-care clinical management of malaria and vector control interventions (e.g., LLINs, IRS) throughout the trial
Provision of a 3-day course of standard, first-line antimalarials (Coartem® or ASAQ Winthrop®) at baseline to clear any malaria parasite infections
Provision of a new LLIN at baseline
Provision of treatment for malaria infection throughout the follow-up period
Encouragement of LLIN use and no instructions to avoid alternative vector control tools (e.g., coils, topicals, aerosol sprays, repellents)

positive controls

Provision of standard-of-care clinical management of malaria and vector control interventions (e.g., LLINs, IRS) throughout the trial

negative controls

None explicitly mentioned

Annotations

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