Vitamin D Status in Healthy Teens

The initial aim of the Vitados cohort (NCT01832623) was to assess native vitamin D [25-(OH)-D] status in a general French population of healthy Caucasian teenagers in association with their bone and cardiovascular status; it allowed to describe normal values for the main phosphate/calcium and bone biomarkers in the total cohort of 100 included healthy teenagers depending on sex and puberty (30 (link)). Exclusion criteria were the following: walking disability, past or ongoing treatment by growth hormone (rhGH) therapy, past intake of oral corticosteroids (for more than 3 months), ongoing treatment with corticosteroids or calcineurin inhibitors, chronic disease with a likely effect on growth (and notably chronic parenteral nutrition, chronic inflammatory disease, systemic disease, chronic renal insufficiency, diabetes mellitus), acute ongoing severe disease (and notably infection or cancer), pregnancy, and an intake of acetylsalicylic acid or anti-inflammatory drugs within the last 3 weeks. Here, we were able to work on the remaining sera of 38 subjects from this cohort.
Demographic, physical, and biochemical data were recorded. Height and weight were presented as the standard deviation score (SDS) for age and sex, and BMI was presented as the percentile for age and sex. The Tanner stage was assessed by an experienced physician. Systolic and diastolic blood pressure (SBP and DBP) were expressed in terms of percentile according to age, sex, and height (34 ).