Snake Venom-Based Fibrin Sealant

Commercially available fibrin sealants consist of human thrombin and fibrinogen, which might transmit infectious diseases [16 ]. Researchers at the Center for the Study of Venoms and Venomous Animals at UNESP (Centro de Estudos de Venenos e Animais Peçonhentos da UNESP), São Paulo State University therefore proposed a new sealant produced from the thrombin-like enzyme extracted from snake venom and animal fibrinogen. The sealant was produced in this study according to the proposed standardization [15 -17 ,21 ]. The product was provided in three microtubes that were stored at -20°C. Upon use, the components were mixed in the previously set proportions to generate a stable clot with a dense fibrin network.