Pristane-Induced Systemic Lupus Erythematosus in Mice

Systemic lupus erythematosus (SLE) was induced by treating mice (at balanced gender ratio) with pristane (2,6,10,14-tetramethylpentadecane; Sigma-Aldrich) as described.(22 (link)) In brief, the animals received a single intraperitoneal pristane injection (0.5ml each) and were monitored by regular weight control and urine as well as blood sampling. The experiment was terminated after 4 months.

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Czeh M., Stäble S., Krämer S., Tepe L., Talyan S., Carrelha J., Meng Y., Heitplatz B., Schwabenland M., Milsom M.D., Plass C., Prinz M., Schlesner M., Andrade-Navarro M.A., Nerlov C., Jacobsen S.E., Lipka D.B, & Rosenbauer F. (2021). DNMT1 deficiency impacts on plasmacytoid dendritic cells in homeostasis and autoimmune disease. Journal of immunology (Baltimore, Md. : 1950), 208(2), 358-370.

Publication 2021

pristane

Animals Intraperitoneal injection Mice Pristane Systemic lupus erythematosus Urine

Corresponding Organization : University of Münster

Other organizations : University of Oxford, John Radcliffe Hospital, MRC Weatherall Institute of Molecular Medicine, German Cancer Research Center, National Center for Tumor Diseases, University of Augsburg, Johannes Gutenberg University Mainz, University Hospital Münster, University of Freiburg, Karolinska Institutet, Karolinska University Hospital

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Variable analysis

independent variables

Pristane (2,6,10,14-tetramethylpentadecane; Sigma-Aldrich)

dependent variables

Weight
Urine
Blood

control variables

Gender ratio of mice

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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