Synthesis and PET Imaging of [18F]PSMA-1007

[18F]PSMA-1007 had been synthesized according to Cardinale et al. (18 (link)). The mean injected activity of [¹⁸F]PSMA-1007 was 299 MBq (min–max: 249–370 MBq). Patients underwent a whole-body PET scan starting 2 h after injection. Scans were performed with a 16-slice Gemini TF big bore in one patient and a Vereos PET/CT scanner in nine patients (all Philips Healthcare, USA). A phantom study was performed and comparable SUV values were obtained in both systems (19 (link)). Both scanners fulfilled the requirements indicated in the European Association of Nuclear Medicine (EANM) imaging guidelines and obtained EANM Research Ltd (EARL). accreditation during acquisition. At the time of the PET scan, either a contrast-enhanced or native diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed for attenuation correction (depending on previous CT scans and contraindications). Please see (19 (link)) for details about reconstruction methods. All systems resulted in a PET image with a voxel size of 2 × 2 × 2 mm³. The uptake of [¹⁸F]PSMA-1007 was quantified in terms of standardized uptake values (SUV) normalized body weight.

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Spohn S.K., Kramer M., Kiefer S., Bronsert P., Sigle A., Schultze-Seemann W., Jilg C.A., Sprave T., Ceci L., Fassbender T.F., Nicolay N.H., Ruf J., Grosu A.L, & Zamboglou C. (2020). Comparison of Manual and Semi-Automatic [18F]PSMA-1007 PET Based Contouring Techniques for Intraprostatic Tumor Delineation in Patients With Primary Prostate Cancer and Validation With Histopathology as Standard of Reference. Frontiers in Oncology, 10, 600690.

Publication 2020

16-slice Gemini TF big bore Vereos PET/CT scanner

Body weight Ct scanner Ct scans Diagnostic ct scan European Nuclear medicine Patients Pet scan Psma 1007 Reconstruction Whole body scan

Corresponding Organization :

Other organizations : University of Freiburg, German Cancer Research Center, University Medical Center Freiburg

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Variable analysis

independent variables

Synthesis protocol used to produce [18F]PSMA-1007

dependent variables

Standardized uptake values (SUV) of [18F]PSMA-1007 uptake

control variables

Injected activity of [18F]PSMA-1007 (mean 299 MBq, range 249-370 MBq)
Time of PET scan after injection (2 hours)
PET/CT scanner models used (Gemini TF big bore and Vereos PET/CT)
Reconstruction methods (see reference 19)
PET image voxel size (2 x 2 x 2 mm3)
Attenuation correction method (contrast-enhanced or native diagnostic CT scan)
Compliance with EANM imaging guidelines and EARL accreditation

positive controls

Phantom study performed to obtain comparable SUV values between the two PET/CT scanner models

negative controls

Not specified

Annotations

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