Retrospective Analysis of Uveal Melanoma Cases

The study design was a retrospective case series. All patients who were newly diagnosed with uveal melanoma and treated at a national referral center (Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland) between 1 January 2018, and 31 December 2021, were extracted from the hospital database and included in the study. This hospital database provides medical data, which include the diagnoses coded according to the International Classification of Diseases, 10th Revision (ICD-10); the 3rd edition of the International Classification of Diseases for Oncology (ICD-O-3) codes; and all performed procedures coded using the International Classification of Diseases, 9th Revision (ICD-9) procedure codes and unique National Health Fund (NHF) codes, corresponding to certain hospital procedures. The hospital database also provides demographical features such as the date of birth and sex of patients. The Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, is the referral center for ophthalmic oncology for adults in Poland. The following data were compiled: the sex of patients and their age at the time of diagnosis; the year of diagnosis; clinical findings such as the laterality of the tumor (right or left eye); intra-ocular localization and cancer stage, according to the TNM classification of malignant tumors (both at the time of diagnosis); and applied treatments including plaque radiotherapy (brachytherapy with iodine-125 or rhutenium-106), proton beam irradiation (PBI), local surgery, and/or enucleation of the eye globe. Tumors were clinically classified as localized in the iris, ciliary body, choroid, or mixed (according to their appearance).