Scopolamine-Induced Cognitive Impairment Model

The administration of scopolamine, an antagonist of muscarinic acetylcholine receptors, causes a temporary blockade of receptors, impaired cognitive functions and cerebral metabolism, which is considered to be a reliable model of AD (Buccafusco, 2009 ). Scopolamine aqueous solution was prepared by dissolving weighed sample in water for injection. A solution of scopolamine was injected intraperitoneally at a dose of 1.5 mg/kg/5 mL once 30 min before testing of the passive avoidancereflex (only on the first day - the day of training).

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Gorin B.I., Tukhovskaya E.A., Ismailova A.M., Slashcheva G.A., Lenina O.A., Petrov K.A., Kazeev I.V, & Murashev A.N. (2023). Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon®). Frontiers in Pharmacology, 14, 1091858.

Publication 2023

Acetylcholine receptors Cognitive functions Metabolism Muscarinic antagonist Scopolamine

Corresponding Organization : Institute of Bioorganic Chemistry

Other organizations : A.E. Arbuzov Institute of Organic and Physical Chemistry, Ministry of Health of the Russian Federation

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Variable analysis

independent variables

Administration of scopolamine, an antagonist of muscarinic acetylcholine receptors

dependent variables

Temporary blockade of receptors
Impaired cognitive functions
Impaired cerebral metabolism

control variables

Dose of scopolamine (1.5 mg/kg/5 mL)
Time of administration (30 min before testing of the passive avoidance reflex)

controls

Positive control: Not mentioned
Negative control: Not mentioned

Annotations

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