Multimodal MRI Brain Volumetry and Lesion Analysis

MRI scans were acquired on a 3 T Siemens Skyra scanner (Yale) and 3 T Philips Ingenuity TF PET/MR scanner or a Philips Gyroscan Intera 1.5 T Nova Dual scanner (Turku). Total brain volumes, derived from non-Gadolinium enhanced T1 sequences, were calculated using mixed voxel segmentation and normalized to head size^{31 (link)}. Automated lesion detection was performed on T2 weighted FLAIR sequences with the LPA algorithm available as part of the lesion segmentation toolbox (LST) (http://www.applied-statistics.de/lst.htm), followed by manual correction using itk-SNAP software version 3.x by three reviewers blinded to the patients’ genotype.

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Ponath G., Lincoln M.R., Levine-Ritterman M., Park C., Dahlawi S., Mubarak M., Sumida T., Airas L., Zhang S., Isitan C., Nguyen T.D., Raine C.S., Hafler D.A, & Pitt D. (2018). Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nature Communications, 9, 5337.

Publication 2018

Ingenuity TF PET/MR scanner Gyroscan Intera 1.5 T Nova Dual scanner

Brain Gadolinium Genotype Head Mri scans Patients

Corresponding Organization :

Other organizations : Yale University, University of Turku, Cornell University, Albert Einstein College of Medicine

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Variable analysis

independent variables

MRI scanner type (3 T Siemens Skyra, 3 T Philips Ingenuity TF PET/MR, or Philips Gyroscan Intera 1.5 T Nova Dual)

dependent variables

Total brain volumes derived from non-Gadolinium enhanced T1 sequences
Automated lesion detection on T2 weighted FLAIR sequences

control variables

Head size (brain volumes normalized to head size)
Manual correction of lesion detection by three reviewers blinded to the patients' genotype

controls

No positive or negative controls were explicitly mentioned.

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