Example 8
GPRC5D targeted 28z CAR18 T cells mediated an anti-myeloma immune response. 1×107 U266 human myeloma cell line cells were injected IV into NSG mice on day 0. On day 4 1×106 GPRC5D targeted or CD19 targeted second generation CAR T cells were injected IV. Imaging on day 11 (day 7 s/p CAR T cell injection) shows that, unlike irrelevant (CD19) targeted CAR T cells; GPRC5D A targeted 28z CAR18 T cells can mediate an anti-tumor response. See
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