Small Animal Radiation Research Platform Dosimetry

Therapeutic exposures were performed using 220 kVp X-rays (broad focus, 0.15 mm Cu filter and a half value layer of 0.93 mm Cu) delivered using the SARRP irradiator in conjunction with collimators to produce a range of field sizes. Additional filtration results from the presence of a transmission monitor (in total: 0.105 mm Cu and 1 mm of FR4 a fibreglass/epoxy mix). For each collimator, dosimetry was performed using an EBT3 film as described before, with the film calibrated following the recommendations of the report of the American Association of Physicists in Medicine Task Group 61 [20 (link), 21 (link)]. Treatment planning and subsequent beam delivery was performed using Muriplan (Xstrahl Ltd, Camberley, Surrey, UK), with targeting and subsequent segmentation performed using the CBCT image [22 (link)].