Detailed Radiation Planning for Hypoxic Cells

Photon planning was done with Raystation treatment planning system (RaySearch Laboratories) based on a CT scan of the hypoxia chamber containing 96-well plates filled with water. Irradiation was performed on a Siemens Artiste (6 MV). For carbon ion delivery, Spread-out Bragg peak (SOBP) was physically optimized with the Treatment Planning for Particles (TRiP98) system, using a 30x30x30 cm³ water phantom positioned at 100 cm source-surface distance (SSD) [17 (link)]. To reduce physical uncertainties on cell survival introduced by the heterogeneous target, a detailed geometry of the utilized 96-well plates was incorporated into a FLUKA Monte Carlo simulation of the Heidelberg Ion Beam Therapy (HIT) beam-line [18 (link)]. Dose maps were generated, with dose uniformity found to be within 2% range in the SOBP region. Carbon dose levels for planned 1, 2, 4 and 6 Gy were corrected accordingly to actual prescribed 0.95, 1.9, 3.8, and 5.64 Gy.

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Klein C., Dokic I., Mairani A., Mein S., Brons S., Häring P., Haberer T., Jäkel O., Zimmermann A., Zenke F., Blaukat A., Debus J, & Abdollahi A. (2017). Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation. Radiation Oncology (London, England), 12, 208.

Publication 2017

Raystation treatment planning system Artiste

Carbon Cell survival Ct scan Delivery Heterogeneous Hypoxia Irradiation Maps Physical Therapy

Corresponding Organization :

Other organizations : National Center for Tumor Diseases, Heidelberg University, University Hospital Heidelberg, Heidelberger Institut für Radioonkologie, German Cancer Research Center, Merck (Germany)

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Variable analysis

independent variables

Radiation type (photon vs. carbon ion)

dependent variables

Cell survival

control variables

CT scan of hypoxia chamber containing 96-well plates filled with water
Irradiation performed on a Siemens Artiste (6 MV)
Spread-out Bragg peak (SOBP) physically optimized with the Treatment Planning for Particles (TRiP98) system
30x30x30 cm^3 water phantom positioned at 100 cm source-surface distance (SSD)
Detailed geometry of the utilized 96-well plates incorporated into a FLUKA Monte Carlo simulation of the Heidelberg Ion Beam Therapy (HIT) beam-line

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