The hDHODH inhibitors (Figure 1A) were synthesized as described previously [16 (link),17 (link)]. Brequinar, uridine, orotic acid (ORO), dihydroorotic acid (DHO), and dipyridamole (DPY) were purchased from Sigma-Aldrich. Remdesivir (RDV) (GS-5734) was obtained by MedChemExpress.
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