Quantitative Assessment of Emphysema Severity

Chest CT examinations were performed with a General Electric (GE) LightSpeed VCT (64-detector) scanner at a radiation exposure of 100 mAs [6] (link), [8] (link). A single expert radiologist, blinded to subject identities and other characteristics, interpreted the CT images using a validated [6] (link). 6-point semi-quantitative visual scoring system to define emphysema severity (0 = none, 1 = trace/minimal, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe), corresponding to 0%, <10%, 10–25%, 26–50%, 51–75%, and >75% visual emphysema [6] (link)–[8] (link). Our group has previously shown these visual emphysema scores are associated with clinically important outcomes in smokers [6] (link)–[8] (link), and the validity and comparability of these assessments with other radiographic measures of emphysema has also been established [2] (link), [3] (link).

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Bon J., Kahloon R., Zhang Y., Xue J., Fuhrman C.R., Tan J., Burger M., Kass D.J., Csizmadia E., Otterbein L., Chandra D., Bhargava A., Pilewski J.M., Roodman G.D., Sciurba F.C, & Duncan S.R. (2014). Autoreactivity to Glucose Regulated Protein 78 Links Emphysema and Osteoporosis in Smokers. PLoS ONE, 9(9), e105066.

Publication 2014

LightSpeed VCT (64-detector) scanner

Chest Electric Emphysema Examinations Radiation exposure Radiographic Radiologist

Corresponding Organization : Indiana University – Purdue University Indianapolis

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Variable analysis

independent variables

Radiation exposure of 100 mAs

dependent variables

Emphysema severity score (0 = none, 1 = trace/minimal, 2 = mild, 3 = moderate, 4 = severe, 5 = very severe)

control variables

Chest CT examinations were performed with a General Electric (GE) LightSpeed VCT (64-detector) scanner
Single expert radiologist, blinded to subject identities and other characteristics, interpreted the CT images using a validated 6-point semi-quantitative visual scoring system

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