Biomarkers of Cardiovascular Disease

Biomarkers measured in this study at baseline included: ST2 (fibrosis); GDF-15 (apoptosis); NT-proBNP (myocyte stretch); cTnI (myocardial injury); hsCRP and IL-6 (inflammation); Cystatin C (renal dysfunction); and D-dimer (thrombosis).^{13 (link)-18 (link)} GDF-15, Cystatin C, and IL-6 were measured using a Quantikine Human Immunoassay (R&D systems, Minneapolis, MN). ST2 was measured using the Presage Assay (Critical Diagnostics, San Diego, CA). CRP was measured using the CardioPhase High Sensitivity C-Reactive Protein Immunoassay (Siemens Medical Solutions Diagnostics, Tarrytown, NY). Troponin was measured using the Advia Centaur TnI-Ultra Assay (Siemens Medical Solutions Diagnostics, Tarrytown, NY). NT-proBNP was measured by the Roche E Modular assay (Roche Diagnostics Corporation, Indianapolis, IN). D-dimer was measured using the Zymutest D-Dimer ELISA (Aniara, West Chester, Ohio). Details regarding sensitivity, range, and coefficients of variation have been published previously^{2 (link)}.

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Scherzer R., Shah S.J., Secemsky E., Butler J., Grunfeld C., Shlipak M.G, & Hsue P.Y. (2018). Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection. Circulation. Heart Failure, 11(4), e004312.

Publication 2018

Quantikine Human Immunoassay CardioPhase High Sensitivity C-Reactive Protein Immunoassay Advia Centaur TnI-Ultra Assay Roche E Modular assay

Apoptosis Assay Biomarkers Cystatin c D dimer Diagnostics Elisa Fibrosis Gdf 15 High sensitivity c reactive protein Human Immunoassay Inflammation Injury Myocardial Myocyte Nt probnp Renal dysfunction Sensitivity Thrombosis Troponin

Corresponding Organization :

Other organizations : San Francisco General Hospital, Northwestern University, Massachusetts General Hospital, University of California, San Francisco

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

ST2 (fibrosis)
GDF-15 (apoptosis)
NT-proBNP (myocyte stretch)
CTnI (myocardial injury)
HsCRP and IL-6 (inflammation)
Cystatin C (renal dysfunction)
D-dimer (thrombosis)

control variables

None explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the input.

Annotations

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