Circadian Rhythm and Diabetes Mouse Models

Male WT C57BL6J mice and C57BL/6-Ins2^Akita/J mice were purchased from the Jackson Laboratory (Bar Harbor, ME). PdxCre;Bmal1^flx/flx and Cry1^-/-;Cry2^-/- mice were produced and maintained on C57BL6J background at the Northwestern University Center for Comparative Medicine (Protocols IS00000466, IS00003253, IS00008732, IS0005838) (Peek et al., 2013 (link); Vitaterna et al., 1999 (link)). Unless otherwise stated, animals were maintained on a 12:12 light:dark cycle and allowed free access to water and regular chow. All animal care and use procedures were conducted in accordance with regulation of the Institutional Animal Care and Use Committee at Northwestern University.