Transgenic Mouse Lines for Cell-Specific Gene Targeting

C57BL/6J and MCH:ICR mice were purchased from CLEA Japan (Tokyo, Japan). Tie2-Cre [5 (link)], LysM-Cre [14 (link)], Pf4-Cre [15 (link)], and mT/mG mice [33 (link)] were obtained from the Jackson Laboratory (Bar Harbor, ME, USA). FLP66 transgenic mice (RBRC01252) [34 (link)] were obtained from RIKEN BRC (Tsukuba, Japan). The generation of Vegfr3-Cre transgenic lines, including the Vegfr3-Cre39 line used in this study, was described previously [25 (link)]. All mice were housed under pathogen-free conditions. All mouse work in this study was approved by the Animal Care and Use Committee of the University of Tokyo and was conducted in accordance with their guidelines (approval nos. 19–13, 19–14, PA11-94 and PA11-95).