The Doppler echo parameter, pulmonary artery acceleration time (PAAT) is considered an echocardiographic indicator of PH (27 (link)). PAAT is the time interval between the onset of systolic pulmonary arterial flow and peak flow velocity. Previous studies have demonstrated that PAAT is inversely proportional to pulmonary vascular resistance (28 (link)-30 (link)). If the pulmonary vascular resistance increases, the pulmonary artery pressure also increases. Doppler echocardiography was used to assess PH on the 28th day following model establishment in the SD rats. A transthoracic closed-chest echocardiography was performed using a Vivid E9 ultrasound system equipped with a 12-MHz transducer (GE Healthcare; Cytiva). The rats were anesthetized by administering an i.p. injection of 3% sodium pentobarbital (40 mg/kg). PAAT was measured near the pulmonary valve on the left side of the chest. EchoPAC™ BT11 software (v.6.5; GE Healthcare; Cytiva) was used to analyze the data.
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Echocardiographic Assessment of Pulmonary Hypertension
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Acceleration
Chest
Doppler echocardiography
Echo
Pressure
Pulmonary artery
Pulmonary valve
Rats
Sodium pentobarbital
Transducer
Transthoracic echocardiography
Ultrasound
Corresponding Organization :
Other organizations : Shihezi University, Jiaxing University
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Variable analysis
independent variables
- Establishment of the SD rat model
- Pulmonary Artery Acceleration Time (PAAT)
- Pulmonary Vascular Resistance
- Pulmonary Artery Pressure
- Anesthesia using 3% sodium pentobarbital (40 mg/kg) administered via i.p. injection
- Echocardiography performed using a Vivid E9 ultrasound system equipped with a 12-MHz transducer (GE Healthcare; Cytiva)
- Data analysis using EchoPAC™ BT11 software (v.6.5; GE Healthcare; Cytiva)
- No positive or negative controls were explicitly mentioned in the provided information.
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