Mouse Model of Endometriosis

The mouse model of endometriosis was performed as described previously [36 (link), 37 (link)]. Donor mice were treated subcutaneously with estradiol benzoate (3 μg/mouse, MCE). One week after the estrogen injection, donor mice were sacrificed and each uterine horn was collected and split longitudinally with a pair of scissors. Carefully mechanical dissected each uterine horn into fragments with a maximal diameter lower than 1 mm, Endometriosis was induced by injecting the uterine horn fragments from two mice intraperitoneally into three recipient mice.

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Zhu S., Zhang J., Xue N., Zhu X., Li F., Dai Q., Qing X., Chen D., Liu X., Wei Z, & Cao Y. (2023). Highly specific neutrophil-mediated delivery of albumin nanoparticles to ectopic lesion for endometriosis therapy. Journal of Nanobiotechnology, 21, 81.

Publication 2023

Donor Endometriosis Estradiol benzoate Estrogen Mice Uterine horn

Corresponding Organization : First Affiliated Hospital of Anhui Medical University

Other organizations : Hefei National Center for Physical Sciences at Nanoscale, University of Science and Technology of China

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Variable analysis

independent variables

Estradiol benzoate (3 μg/mouse, MCE) treatment in donor mice

dependent variables

Endometriosis development in recipient mice

control variables

Uterine horn fragments from two donor mice were injected intraperitoneally into three recipient mice

controls

No positive or negative controls were explicitly mentioned in the input.

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