Live Cell Imaging of Spindle Dynamics
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Variable analysis
- Time interval for image acquisition (1 min vs. 30 s)
- Z-spacing for image acquisition (1 µm vs. 0.5 µm)
- Total z-stack depth (15 µm vs. 3 µm)
- Visualization of monopolar spindles
- Visualization of bipolar spindles
- Visualization of kinetochore pairs
- Temperature (37°C)
- Microscope equipment (Leica DM4000 confocal microscope, 100× 1.4 NA oil immersion objective, XY Piezo-Z stage, CSU10 spinning disk, electron multiplier charge-coupled device camera, laser merge module with 488- and 593-nm lasers)
- Imaging method (live imaging vs. fixed cell imaging)
- Positive control: Not explicitly mentioned.
- Negative control: Not explicitly mentioned.
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