Multimodal Neuroimaging Protocol for [18F]fallypride PET and MRI

A magnetized prepared rapid gradient echo (MP-RAGE) magnetic resonance image (MRI) was acquired using a Siemens 3T Trio-Tim for anatomic coregistration and processing of PET data. Acquisition of [¹⁸F]fallypride (FAL) data was similar to that described previously (Albrecht et al. 2014 (link)). Briefly, FAL was synthesized in the Department of Radiology and Imaging Sciences radiochemistry facilities (Gao et al. 2010 (link)). FAL PET scans were acquired on a Siemens ECAT HR+ (3D mode; septa retracted). FAL PET scans were initiated with an IV FAL infusion into the antecubital vein over the course of 1.5 minutes. The dynamic PET acquisition was split into two segments for subject comfort (Christian et al. 2006 (link)). The first half of dynamic acquisition was 70 min (6 × 30s, 7 × 60s, 10 × 120s, 10 × 300s). Following this segment, the subject was removed from the scanner for a ~20 min break period to stretch and use the restroom if needed. The second half of dynamic acquisition lasted 80 min (16 × 300s). A schematic of the scan day timeline is shown in Online Resource 1.