We also examined T2D association summary statistics at lead SNPs for 37 established T1D susceptibility loci. For each of these SNPs, we reported the allelic OR (aligned to the T2D risk-allele) and P-values in: (i) our Stage 1 T2D meta-analysis; and (ii) a GWAS meta-analysis of 7,514 T1D cases and 9,045 population controls from European descent populations from the Type 1 Diabetes Genetics Consortium35 (link).
Comprehensive Analysis of T2D Genetic Associations
We also examined T2D association summary statistics at lead SNPs for 37 established T1D susceptibility loci. For each of these SNPs, we reported the allelic OR (aligned to the T2D risk-allele) and P-values in: (i) our Stage 1 T2D meta-analysis; and (ii) a GWAS meta-analysis of 7,514 T1D cases and 9,045 population controls from European descent populations from the Type 1 Diabetes Genetics Consortium35 (link).
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Corresponding Organization : University of Oxford
Other organizations : Massachusetts Institute of Technology, Broad Institute, University of Michigan–Ann Arbor, deCODE Genetics (Iceland), Karolinska Institutet, University of Cambridge, Helmholtz Zentrum München, Inserm, University of Tartu, University of Edinburgh, Wellcome Sanger Institute, Addenbrooke's Hospital, Medical Research Council, MRC Epidemiology Unit, Ludwig-Maximilians-Universität München, Zimmer Biomet (Germany), University of Duisburg-Essen, Institut Pasteur de Lille, Centre National de la Recherche Scientifique, Finnish Institute for Health and Welfare, Framingham Heart Study, National Heart Lung and Blood Institute, Boston University, Center for Human Genetics, Massachusetts General Hospital, University of North Carolina at Chapel Hill, Johns Hopkins University, Harvard University, National Institutes of Health, National Human Genome Research Institute, Norwegian University of Science and Technology, University of Western Australia, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Amsterdam, Academic Medical Center, University of Eastern Finland, Kuopio University Hospital, Institute for Molecular Medicine Finland, University of Exeter, Scania (Sweden), Lund University, University of Iceland, Centre Hospitalier Sud Francilien, Ninewells Hospital, University of Dundee, Icelandic Heart Association, University of Helsinki, Karolinska University Hospital, Deutsches Diabetes-Zentrum e.V., Heinrich Heine University Düsseldorf, Reykjavík University, National University Hospital of Iceland, Sir Charles Gairdner Hospital, University of Bonn, University General Hospital Attikon, South Karelia Central Hospital, University College London, Universität Ulm, Centro Cardiologico Monzino, Erasmus MC, Uppsala University, Centre de recherche en Epidémiologie et Santé des Populations, Folkhälsans Forskningscentrum, University of Maryland, Baltimore, UiT The Arctic University of Norway, Uppsala University Hospital, Harokopio University of Athens, University of Oulu, Finnish Diabetes Association, Central Finland Health Care District, Cedars-Sinai Medical Center, West German Heart and Vascular Center Essen, Deutsches Herzzentrum München, The University of Texas Health Science Center at Houston, Brigham and Women's Hospital, University of Minnesota, National Institute for Health Research, Churchill Hospital
Protocol cited in 194 other protocols
Variable analysis
- None specified
- Glycemic traits in non-diabetic individuals (fasting glucose, fasting insulin, HOMA-B, HOMA-IR)
- Plasma lipid concentrations (total cholesterol, LDL, HDL, triglycerides)
- T2D association at lead SNPs for 37 established T1D susceptibility loci
- None specified
- None specified
- None specified
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