Continuous variables were checked for normal distribution using the Shapiro-Wilk test and are presented as median with interquartile range (IQR). Biventricular volumes and LV mass were indexed to body surface area. Dependent variables were tested using the Wilcoxon signed-rank test. Agreement of manual and automated analyses as well as intra- and inter-observer variability was assessed first using Bland-Altman analysis [mean difference between measurements with 95% confidence interval (CI)] [14 (link)], second intra-class correlation coefficients (ICC) based on a model of absolute agreement, considered excellent if ICC > 0.74, good between 0.60 and 0.74, fair between 0.4 and 0.59 and poor below 0.4 [15 (link)], and third the coefficient of variation (CoV, = standard deviation [SD] of the differences divided by the mean) [16 (link), 17 (link)]. P-values provided are two-sided, an alpha level below 0.05 was considered statistically significant. Statistical analyses were performed using IBM SPSS Statistic Software Version 24 (International Business Machines, Armonk, New York, USA) and Microsoft Excel (Microsoft, Redmond, Washington, USA).
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