Example 45
A mixture of compound 45-1 (15 mg, 0.03 mmol, 1 eq) and m-CPBA (6.4 mg, 0.02 mmol, 0.8 eq), in DCM (2 mL) was stirred at 25° C. for 1 hr. LC-MS showed the desired compound was detected. The reaction mixture was diluted with H2O (6 mL) and the mixture was extracted with EA (8 mL*3). The combined organic phase was washed with brine (8 mL*2), dried with anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-HPLC. The title compound (2 mg, 4.7 umol, 12.8% yield) was obtained as white solid. LCMS (ESI): RT=0.780 min, mass calc. for C22H20F3NO2S 419.46, m/z found 420.0 [M+H]+; 1H NMR (400 MHz, CD3OD) δ 1.21 (d, J=6.53 Hz, 6H) 2.85 (s, 3H) 4.18 (quin, J=6.59 Hz, 1H) 7.61-7.71 (m, 2H) 7.68-7.69 (m, 1H) 7.76-7.85 (m, 3H) 7.87-7.95 (m, 1H) 8.33 (s, 1H) 8.48 (d, J=1.26 Hz, 1H).
