Adenoviral vectors were generated as previously described (12 (link)). Briefly, the coding sequences (CDS) for the transgenes encoded in Adenoviral vectors (the corresponding amino acidic sequences are listed in Supplementary Table S1) were synthesized as phosphorylated gBlock dsDNA fragments (IDT). HA tags were added at the N- and C terminus of each transgene. The CDS for all the constructs were generated by Gibson assembly (New England Biolabs) and cloned into the respective shuttle plasmid containing the CMV promoter with two TetO operator repeats and a BGH polyA. The expression cassettes were then transferred into pGAd plasmid, containing the E1/E3/E4 deleted in which the E4 is replaced with Ad5 E4 ORF6. The transgene cassettes were introduced in the E1 deletion locus of related pAdeno by homologous recombination in BJ5183 cells (Agilent). GAd vectors were then produced by transfection of adherent M9 cells (293 cells derivative) with Lipofectamine 2000 (Invitrogen) and amplification in suspension M9 cells. Vectors were then purified from infected cells by Vivapure Adenopack 20 RT (Sartorius). The titer of each vector was determined by qPCR and expressed as viral particles (vp) per mL.