Cardiac Biomarkers and Pulmonary Function in Systemic Sclerosis

All participants underwent two CMR scans (visit 1, visit 2) at least 1 year apart. Patients’ follow‐up ended in August 2018. Clinical data were collected at both visits and included demographics, disease subtype and duration, organ involvement, and current and any change in DMARD and/or vasodilator treatment, including calcium channel blockers (CCBs), iloprost, sildenafil, bosentan, and angiotensin‐converting enzyme inhibitor (ACEI) between the two visits. Iloprost infusion was administered as a 3‐day schedule every 3 months at a dosing regimen of 100 μg, as per Leeds Teaching Hospital National Health Service trust protocol. Serum samples were collected for high‐sensitivity troponin I (hs‐TnI) and N‐terminal pro–brain natriuretic peptide (NT‐proBNP) testing at both visits. hs‐TnI was measured on a Siemens Advia XPT system (Advia Chemistry XPT and Advia Centaur XPT Immunoassay) and NT‐proBNP was measured on Cobas 6000 (immunochemistry module Cobas e601) at both visits. Patients had annual pulmonary function tests (PFTs) performed as part of routine clinical assessment. The PFT measures approximating to each CMR visit were recorded.

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Dumitru R.B., Bissell L., Erhayiem B., Fent G., Kidambi A., Abignano G., Greenwood J.P., Biglands J., Del Galdo F., Plein S, & Buch M.H. (2023). Subclinical Systemic Sclerosis Primary Heart Involvement by Cardiovascular Magnetic Resonance Shows No Significant Interval Change. ACR Open Rheumatology, 5(2), 71-80.

Publication 2023

Angiotensin converting enzyme inhibitor Bosentan Brain natriuretic peptide Calcium channel blockers Dmard Iloprost Immunoassay National health service Nt probnp Patients Regimen Scans Sensitivity Serum Sildenafil Troponin i Vasodilator

Corresponding Organization : University of Manchester

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Variable analysis

independent variables

Time (at least 1 year between the two visits)

dependent variables

High-sensitivity troponin I (hs-TnI)
N-terminal pro–brain natriuretic peptide (NT-proBNP)
Pulmonary function tests (PFTs)

control variables

Demographics
Disease subtype and duration
Organ involvement
Changes in DMARD and/or vasodilator treatment, including calcium channel blockers (CCBs), iloprost, sildenafil, bosentan, and angiotensin‐converting enzyme inhibitor (ACEI) between the two visits
Iloprost infusion administration schedule (3-day schedule every 3 months at a dosing regimen of 100 μg)

positive controls

Not specified

negative controls

Not specified

Annotations

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