Measuring Mechanical Hyperalgesia in Mice
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Corresponding Organization : The University of Texas MD Anderson Cancer Center
Other organizations : The University of Texas Health Science Center at Houston
Protocol cited in 1 other protocol
Variable analysis
- Treatment
- Mechanical hyperalgesia (50% paw withdrawal threshold)
- Mice were placed in a plastic cage (10×10×13 cm^3) with a mesh floor for 30 min prior to testing
- Animals were placed on a wire grid floor
- Von Frey hairs were applied by an investigator blinded to treatment
- Positive control: Clear paw withdrawal, shaking, or licking were considered as nociceptive-like responses
- Negative control: Ambulation was considered an ambiguous response, and in such cases, the stimulus was repeated
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