To study protein–protein interactions at crossover targets, the STRING database19 (link) (https://stringdb.org/ ) was used to construct a PPI network of crossover genes of AM sapiens for vitiligo and COVID-19. "Homo sapiens" was selected in the parameter Organism, "Medium confidence 0.400)" was selected in the "Minimum required interaction score", and the other parameters were kept at their default values. Then, we filtered out the top 5 ranked core crossover genes by cytohubba plugin in Cytoscape software.
Finally, we constructed the "active ingredient-crossover genes" network by Cytoscape software and screened the top 10 ranked core ingredients. The core crossover geness in the PPI network were matched with those in the "active ingredient-crossover geness" network and imported into the Venny 2.1 online website, which was presented as a Venn diagram. The overlap between the two crossover) is the most important core crossover target for AM for vitiligo and COVID-19.
Finally, we constructed the "active ingredient-crossover genes" network by Cytoscape software and screened the top 10 ranked core ingredients. The core crossover geness in the PPI network were matched with those in the "active ingredient-crossover geness" network and imported into the Venny 2.1 online website, which was presented as a Venn diagram. The overlap between the two crossover) is the most important core crossover target for AM for vitiligo and COVID-19.
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