The PET imaging was performed according to the previous reports [26 (link),28 (link)]. T1-weighted MR anatomical images were acquired on a 3.0 T scanner (GE Discovery 750, Milwaukee, WI, USA). The rhesus was anesthetized with ketamine (10 mg/kg; intramuscular injection). A circular 32-channel array head coil was placed on top of the monkey’s head. The whole-brain images were acquired with a 3D Bravo T1 sequence.
The male rhesus (weight range 9.48–10.96 kg) underwent PET (GE Discovery Elite 690, Chicago, IL, USA). The rhesus was anesthetized with ketamine (10 mg/kg; Intramuscular Injection), and then 2% isoflurane and 98% oxygen were used. A solution of [18F]Favipiravir (3.9–5.6 mCi) was injected, followed by a dynamic PET scan of the head or lung for 60 min.
The male rhesus (weight range 9.48–10.96 kg) underwent PET (GE Discovery Elite 690, Chicago, IL, USA). The rhesus was anesthetized with ketamine (10 mg/kg; Intramuscular Injection), and then 2% isoflurane and 98% oxygen were used. A solution of [18F]Favipiravir (3.9–5.6 mCi) was injected, followed by a dynamic PET scan of the head or lung for 60 min.
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